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The authors conclude that chronic methamphetamine-handled rats assign increased motivational values to massive rewards. But the dopamine blockers had minimal effect on rats who gambled without the flashing lights and sound cues. The rats, who gambled for sugary treats, normally learn how to keep away from the risky options. In the methamphetamine-handled rats, the researchers discovered evidence of neural activation within the insular cortex, nucleus accumbens, and striatum related to altered decision making. Further, after receiving the massive reward, the methamphetamine-handled rats exhibited “win-keep” habits, choosing the H-H arm more often in subsequent trials than did the management rats, regardless of the likelier damaging end result of the quinine pellet. Additionally, when the methamphetamine-handled rats received the quinine pellet in the L-L arm, they switched to the H-H arm on the subsequent attempt far more ceaselessly than the control rats. They additional explored the neurological modifications precipitated by methamphetamine therapy by subjecting the rats to c-Fos immunohistochemistry, reporting numerous results

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[Author]

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